Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and
intellectual disability (ID), are pervasive, often lifelong disorders, lacking evidence‐based …

Frailty can be viewed as a state of physiological decline that increases susceptibility to
adverse health outcomes. This loss of physiological reserve means that even small stressors …

For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and
inflammation is a centrally important hallmark,,,,,–. Here we examined whether IL-11, a pro …

The ability to investigate therapeutic interventions in animal models of neurodegenerative
diseases depends on extensive characterization of the model (s) being used. There are …

Abstract Three-dimensional (3D) bioprinting is a highly effective technique for fabricating cell-
loaded constructs in tissue engineering. However, the versatility of fabricating precise and …

Tryptophan metabolism through the kynurenine pathway influences molecular processes
critical to healthy aging including immune signaling, redox homeostasis, and energy …

The number of people aged over 65 is expected to double in the next 30 years. For many,
living longer will mean spending more years with the burdens of chronic diseases such as …

Over 5 million Americans and 50 million individuals worldwide are living with Alzheimer's
disease (AD). The progressive dementia associated with AD currently has no cure. Although …

Musculoskeletal aging encompasses the decline in bone and muscle function, leading to
conditions such as frailty, osteoporosis, and sarcopenia. Unraveling the underlying …

Classical laboratory strains show limited genetic diversity and do not harness natural
genetic variation. Mouse models relevant to Alzheimer's disease (AD) have largely been …