A naturally occurring transmissible spongiform encephalopathy (TSE) of mule deer was first
reported in Colorado and Wyoming in 1967 and has since spread to other members of the …

Since chronic wasting disease (CWD) was first identified nearly 50 years ago in a captive
mule deer herd in the Rocky Mountains of the United States, it has slowly spread across …

Prions propagate as multiple strains in a wide variety of mammalian species. The detection
of all such strains by a single ultrasensitive assay such as Real Time Quaking-induced …

Chronic wasting disease (CWD) is an emergent, rapidly spreading prion disease of cervids.
Shedding of infectious prions in saliva and urine is thought to be an important factor in CWD …

Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies
through a process involving the templated conversion of the normal cellular prion protein …

Chronic wasting disease (CWD) is a fatal prion disease of wild and captive cervids in North
America. Prions are infectious agents composed of a misfolded version of a host-encoded …

Hypochlorous acid (HOCl) is produced naturally by neutrophils and other cells to kill
conventional microbes in vivo. Synthetic preparations containing HOCl can also be effective …

In co** with prion diseases, it is important to have tests that are practical enough for
routine applications in medicine, agriculture, wildlife biology, and research, yet sensitive …

The minimum infectious dose required to induce CWD infection in cervids remains unknown,
as does whether peripherally shed prions and/or multiple low dose exposures are important …

Rapid and sensitive detection of prions is important in managing prion diseases. The real-
time quaking-induced conversion (RT-QuIC) assay for prion seeding activity has been …