Cell–extracellular matrix mechanotransduction in 3D

A Saraswathibhatla, D Indana… - Nature Reviews Molecular …, 2023 - nature.com
Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Self-healing injectable hydrogels for tissue regeneration

P Bertsch, M Diba, DJ Mooney… - Chemical …, 2022 - ACS Publications
Biomaterials with the ability to self-heal and recover their structural integrity offer many
advantages for applications in biomedicine. The past decade has witnessed the rapid …

Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles

S Choi, KY Lee, SL Kim, LA MacQueen, H Chang… - Nature materials, 2023 - nature.com
Hydrogels are attractive materials for tissue engineering, but efforts to date have shown
limited ability to produce the microstructural features necessary to promote cellular self …

Harnessing the potential of hydrogels for advanced therapeutic applications: Current achievements and future directions

P Lu, D Ruan, M Huang, M Tian, K Zhu… - Signal transduction and …, 2024 - nature.com
The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Multifunctional hydrogels for the healing of diabetic wounds

T **ang, Q Guo, L Jia, T Yin, W Huang… - Advanced …, 2024 - Wiley Online Library
The healing of diabetic wounds is hindered by various factors, including bacterial infection,
macrophage dysfunction, excess proinflammatory cytokines, high levels of reactive oxygen …

Light-based vat-polymerization bioprinting

R Levato, O Dudaryeva… - Nature Reviews …, 2023 - nature.com
Light-based vat-polymerization bioprinting enables computer-aided patterning of 3D cell-
laden structures in a point-by-point, layer-by-layer or volumetric manner, using vat (vats) …

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

H Cao, L Duan, Y Zhang, J Cao, K Zhang - Signal transduction and …, 2021 - nature.com
Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

[HTML][HTML] 3D cell culture systems: tumor application, advantages, and disadvantages

O Habanjar, M Diab-Assaf, F Caldefie-Chezet… - International journal of …, 2021 - mdpi.com
The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …

Directed cell migration towards softer environments

A Isomursu, KY Park, J Hou, B Cheng, M Mathieu… - Nature materials, 2022 - nature.com
How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis—cell migration towards increasing …

Antimicrobial peptides: A new hope in biomedical and pharmaceutical fields

A Moretta, C Scieuzo, AM Petrone, R Salvia… - Frontiers in cellular …, 2021 - frontiersin.org
Antibiotics are essential drugs used to treat pathogenic bacteria, but their prolonged use
contributes to the development and spread of drug-resistant microorganisms. Antibiotic …