Annotating the functional properties of gene products, ie, RNAs and proteins, is a
fundamental task in biology. The Gene Ontology database (GO) was developed to …

The biological redundancies in molecular networks of complex diseases limit the efficacy of
many single drug therapies. Combination therapeutics, as a common therapeutic method …

Drug repositioning, the process of discovering, validating, and marketing previously
approved drugs for new indications, is of growing interest to academia and industry due to …

Background The associations between genes and diseases are of critical significance in
aspects of prevention, diagnosis and treatment. Although gene-disease relationships have …

Repositioning of previously approved drugs is a promising methodology because it reduces
the cost and duration of the drug development pipeline and reduces the likelihood of …

Enabling precision medicine requires develo** robust patient stratification methods as
well as drugs tailored to homogeneous subgroups of patients from a heterogeneous …

Objective: Drug repositioning is a promising methodology for reducing the cost and duration
of the drug discovery pipeline. We sought to develop a computational repositioning method …

Identifying disease-related genes is of importance for understanding of molecule
mechanisms of diseases, as well as diagnosis and treatment of diseases. Many …

Gene Ontology (GO) uses structured vocabularies (or terms) to describe the molecular
functions, biological roles, and cellular locations of gene products in a hierarchical ontology …

Pharmacovigilance (PV) databases record the benefits and risks of different drugs, as a
means to ensure their safe and effective use. Creating and maintaining such resources can …