Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Non-alcoholic fatty liver disease (NAFLD) is one the fastest emerging manifestations of the
metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form …

Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-
associated disorders in short-lived species, from unicellular organisms to laboratory mice …

Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified
cellular housekee** are the hallmarks of improved healthspan and extended lifespan …

Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

Fatty acid trafficking in cells affects many aspects of cellular function3). Fatty acids act both
as an energy source and as signals for metabolic regulations including gene expression …

While the liver demonstrates remarkable resilience during aging, there is growing evidence
that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and …

Recent evidence points to a strong relationship between increased mitochondrial
biogenesis and increased survival in eukaryotes. Branched-chain amino acids (BCAAs) …

During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …