Disorders of the enteric nervous system—a holistic view

B Niesler, S Kuerten, IE Demir… - … reviews Gastroenterology & …, 2021‏ - nature.com
The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …

TRPM8 channels: A review of distribution and clinical role

Y Liu, R Mikrani, Y He, MMFA Baig, M Abbas… - European journal of …, 2020‏ - Elsevier
Ion channels are important therapeutic targets due to their plethoric involvement in
physiological and pathological consequences. The transient receptor potential cation …

[HTML][HTML] Recent progress in TRPM8 modulation: an update

R González-Muñiz, MA Bonache… - International journal of …, 2019‏ - mdpi.com
The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal
ion channel, activated by low temperatures (< 28° C), pressure, and cooling compounds …

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies

M Camilleri, A Zhernakova, I Bozzarelli… - Nature Reviews …, 2022‏ - nature.com
The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and probably
involves genetic predisposition and the effect of environmental factors. Unlike other …

[HTML][HTML] TRPM8 channels: Advances in structural studies and pharmacological modulation

C Izquierdo, M Martín-Martínez… - International journal of …, 2021‏ - mdpi.com
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …

Human local adaptation of the TRPM8 cold receptor along a latitudinal cline

FM Key, MA Abdul-Aziz, R Mundry, BM Peter… - PLoS …, 2018‏ - journals.plos.org
Ambient temperature is a critical environmental factor for all living organisms. It was likely an
important selective force as modern humans recently colonized temperate and cold …

[HTML][HTML] Update S3-leitlinie reizdarmsyndrom: definition, pathophysiologie, diagnostik und therapie. gemeinsame leitlinie der deutschen gesellschaft für …

P Layer, V Andresen, H Allescher… - Zeitschrift für …, 2021‏ - thieme-connect.com
Auch wurden ähnlich wie bei der Vorgängerleitlinie die Empfehlungen zum kindlichen
Reizdarmsyndrom und Empfehlungen zur Abgrenzung intestinaler Motilitätsstörungen …

Sex-bias in irritable bowel syndrome: linking steroids to the gut-brain axis

SY So, TC Savidge - Frontiers in Endocrinology, 2021‏ - frontiersin.org
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is more common
in females. Despite its high global incidence, the disease mechanism is still unclear and …

Female-specific association between variants on chromosome 9 and self-reported diagnosis of irritable bowel syndrome

F Bonfiglio, T Zheng, K Garcia-Etxebarria, F Hadizadeh… - Gastroenterology, 2018‏ - Elsevier
Background & Aims Genetic factors are believed to affect risk for irritable bowel syndrome
(IBS), but there have been no sufficiently powered and adequately sized studies. To identify …

Cannabis pharmacogenomics: a path to personalized medicine

M Babayeva, ZG Loewy - Current Issues in Molecular Biology, 2023‏ - mdpi.com
Cannabis and related compounds have created significant research interest as a promising
therapy in many disorders. However, the individual therapeutic effects of cannabinoids and …