The development of organometallic catalysis has greatly expanded the synthetic chemist
toolbox compared to only exploiting “classical” organic chemistry. Although more widely …

The ability to perform'new-to-nature'chemical reactions within living cells and organisms is
transforming the way in which scientists interrogate and/or manipulate biological processes …

Bioorthogonal catalysis using transition-metal-based complexes (TMCs) is a promising
approach for converting substrates to desired products in complex cellular media. Notably …

The development of transition metal-based catalytic platforms that promote bioorthogonal
reactions inside living cells remains a major challenge in chemical biology. This is …

Nitroreductases (NTRs) constitute an important class of oxidoreductase enzymes that have
evolved to metabolize nitro-containing compounds. Their unique characteristics have …

Performing abiotic synthetic transformations in live cell environments represents a new,
promising approach to interrogate and manipulate biology and to uncover new types of …

Antibacterial resistance is growing in the world and is becoming a global threat to public
health. In this project, we have checked the particular role of polyvinylpyrrolidone in the …

Imaging abnormal copper/iron with effective fluorescent tools is essential to
comprehensively put insight into many pathological events. However, conventional …

Recent years have witnessed a considerable progress in research aimed at merging
transition metal catalysis with chemical and cell biology. Therefore, a crescent number of …

The palladium-mediated uncaging reaction of allene substrates remains a promising yet
often overlooked strategy in the realm of bioorthogonal chemistry. This method exhibits high …