A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …

In the past two decades, much evidence has accumulated unequivocally demonstrating that
child abuse and neglect is associated with a marked increase in risk for major psychiatric …

Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene
studies have identified genetic variants associated with cardiovascular diseases, metabolic …

Major depressive disorder (MDD) is highly disabling and typically runs a recurrent course.
Knowledge about prevention of relapse and recurrence is crucial to the long-term welfare of …

During the last decades, schizophrenia has been regarded as a developmental disorder.
The neurodevelopmental hypothesis proposes schizophrenia to be related to genetic and …

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for the critical process of one-
carbon metabolism involving folate and homocysteine metabolisms. It is known that some …

Background Childhood trauma increases the risks of both depression and dysfunctional
emotion regulation, which is a factor that has been strongly linked to depression. Because of …

The B vitamins folic acid, vitamin B12 and B6 are essential for neuronal function, and severe
deficiencies have been linked to increased risk of neurodevelopmental disorders …

Background: Cognitive behavioural therapy (CBT) is an effective psychological treatment for
major depressive disorder, although some patients experience a return of symptoms after …