Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters
The in vivo pathogenicity, transmissibility, and fitness of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) Omicron (B. 1.1. 529) variant are not well …
syndrome coronavirus 2 (SARS-CoV-2) Omicron (B. 1.1. 529) variant are not well …
[HTML][HTML] Enterovirus A71 antivirals: past, present, and future
Abstract Enterovirus A71 (EV-A71) is a significant human pathogen, especially in children.
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …
COVID-19 drug discovery and treatment options
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
T Kruse, C Benz, DH Garvanska, R Lindqvist… - Nature …, 2021 - nature.com
Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host
factors. However, most current large-scale methods do not identify this important class of …
factors. However, most current large-scale methods do not identify this important class of …
[HTML][HTML] A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo
Summary" Pan-coronavirus" antivirals targeting conserved viral components can be
designed. Here, we show that the rationally engineered H84T-banana lectin (H84T …
designed. Here, we show that the rationally engineered H84T-banana lectin (H84T …
SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis
W Zhao, X Wang, L Han, C Zhang, C Wang… - Nature …, 2024 - nature.com
Activated Wnt/β-catenin pathway is a key genetic event in liver cancer development. Solute
carrier (SLC) transporters are promising drug targets. Here, we identify SLC13A3 as a drug …
carrier (SLC) transporters are promising drug targets. Here, we identify SLC13A3 as a drug …
An explainable AI-driven biomarker discovery framework for Non-Small Cell Lung Cancer classification
Abstract Non-Small Cell Lung Cancer (NSCLC) exhibits intrinsic heterogeneity at the
molecular level that aids in distinguishing between its two prominent subtypes—Lung …
molecular level that aids in distinguishing between its two prominent subtypes—Lung …
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Extrapulmonary complications of different organ systems have been increasingly recognized
in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited …
in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited …
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …
SARS-CoV-2 exploits host DGAT and ADRP for efficient replication
Abstract Coronavirus Disease 2019 (COVID-19) is predominantly a respiratory tract infection
that significantly rewires the host metabolism. Here, we monitored a cohort of COVID-19 …
that significantly rewires the host metabolism. Here, we monitored a cohort of COVID-19 …