Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and
severely limits brain penetration of systemically administered drugs, resulting in ineffective …

Inhibited immune response and low levels of delivery restrict starvation cancer therapy
efficacy. Here, we report on the co-delivery of glucose oxidase (GOx) and indoleamine 2, 3 …

Biotherapy has recently become a hotspot research topic with encouraging prospects in
various fields due to a wide range of treatments applications, as demonstrated in preclinical …

The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …

Tumor penetration is important for effectively tumor targeting drug delivery. Recently, many
researches are published to overcome the barriers that restrict tumor penetration and …

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Abstract Alzheimer's disease (AD), as a progressive and irreversible brain disorder, remains
the most universal neurodegenerative disease. No effective therapeutic methods are …

Nanoparticles have now long demonstrated capabilities that make them attractive to use in
biology and medicine. Some of them, such as lipid nanoparticles (SARS-CoV-2 vaccines) or …

Transition‐metal dyshomeostasis has been identified as a critical pathogenic factor for the
aggregates of amyloid‐beta (Aβ) peptide, which is associated with the onset and …