Cluster headache is a debilitating primary headache disorder that affects approximately
0.1% of the population worldwide. Cluster headache attacks involve severe unilateral pain …

Nimodipine is a 1, 4-dihydropyridine-derivative Ca2+-channel blocker developed
approximately 30 years ago. It is highly lipophilic, crosses the blood-brain barrier, and …

SYNOPSIS Chronic Cluster Headache (CCH) treatment is troublesome; since there are no
pain‐free periods, it must be continuous. The most effective CCH prophylactic drug today is …

Background: High dose verapamil is an increasingly common preventive treatment in cluster
headache (CH). Side effects include atrioventricular block and bradycardia, although their …

The trigeminal autonomic cephalgias (TACs) are a group of primary headache disorders
characterised by unilateral trigeminal distribution pain that occurs in association with …

We report the initial results of the first controlled double-blind trial of nomodipine, a calcium
channel antagonist, in the acute and prophylactic treatment of patients with treatment …

Background The trigeminal autonomic cephalalgias (TACs) are highly disabling primary
headache disorders. There are several issues that remain unresolved in the understanding …

Trigeminal autonomic cephalalgias (TACs) are a group of primary headaches including
cluster headache (CH), paroxysmal hemicrania (PH) and short-lasting unilateral …

SYNOPSIS An 8‐month, double‐blind, placebo‐controlled crossover trial was carried out on
the use of nimodipine in migraine prophylaxis in 37 patients aged 7 to 18 years old. After a 4 …

Based on published reports of controlled double-blind studies, the efficacy of β-receptor
blockers and calcium antagonists in the prophylactic treatment of migraine is reviewed …