Bionanoparticles in cancer imaging, diagnosis, and treatment

Y Li, Q Bao, S Yang, M Yang, C Mao - View, 2022 - Wiley Online Library
Biological molecules such as DNA, proteins, and lipids can be assembled into naturally
existing nanoparticles, such as bacterial viruses (also called bacteriophages or phages) …

[HTML][HTML] Engineered M13 phage as a novel therapeutic bionanomaterial for clinical applications: From tissue regeneration to cancer therapy

C Chang, W Guo, X Yu, C Guo, N Zhou, X Guo… - Materials Today Bio, 2023 - Elsevier
Bacteriophages (phages) are nanostructured viruses with highly selective antibacterial
properties that have gained attention beyond eliminating bacteria. Specifically, M13 phages …

[HTML][HTML] A comprehensive review on phage therapy and phage-based drug development

L Cui, S Watanabe, K Miyanaga, K Kiga, T Sasahara… - Antibiotics, 2024 - mdpi.com
Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining
momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) …

T7 phage as an emerging nanobiomaterial with genetically tunable target specificity

H Yue, Y Li, M Yang, C Mao - Advanced Science, 2022 - Wiley Online Library
Bacteriophages, also known as phages, are specific antagonists against bacteria. T7 phage
has drawn massive attention in precision medicine owing to its distinctive advantages, such …

Highly effective stroke therapy enabled by genetically engineered viral nanofibers

X Liu, M Yang, F Lei, Y Wang, M Yang… - Advanced …, 2022 - Wiley Online Library
Stroke results in the formation of a cavity in the infarcted brain tissue. Angiogenesis and
neurogenesis are poor in the cavity, preventing brain‐tissue regeneration for stroke therapy …

Harnessing virus flexibility to selectively capture and profile rare circulating target cells for precise cancer subty**

HD Li, YQ Chen, Y Li, X Wei, SY Wang, Y Cao… - Nature …, 2024 - nature.com
The effective isolation of rare target cells, such as circulating tumor cells, from whole blood is
still challenging due to the lack of a capturing surface with strong target-binding affinity and …

Viruses as biomaterials

T Yang, Y Chen, Y Xu, X Liu, M Yang, C Mao - Materials Science and …, 2023 - Elsevier
Viruses lacking the capacity to infect mammals exhibit minimal toxicity, good
biocompatibility, and well-defined structures. As self-organized biomolecular assemblies …

Selectively suppressing tumor angiogenesis for targeted breast cancer therapy by genetically engineered phage

Y Li, X Qu, B Cao, T Yang, Q Bao, H Yue… - Advanced …, 2020 - Wiley Online Library
Antiangiogenesis is a promising approach to cancer therapy but is limited by the lack of
tumor‐homing capability of the current antiangiogenic agents. Angiogenin, a protein …

Stemness maintenance and massproduction of neural stem cells on poly L‐lactic acid nanofibrous membrane based on piezoelectriceffect

X Lu, C Sun, L Chen, Z Feng, H Gao, S Hu, M Dong… - Small, 2022 - Wiley Online Library
Neural stem cells (NSCs) therapy is promising for treating neurodegenerative disorders and
neural injuries. However, the limited in vitro expansion, spontaneous differentiation, and …

Integration of genetically engineered virus nanofibers and fibrin to form injectable fibrous neuron-rich hydrogels and enable neural differentiation

Y Chen, X Liu, M Yang, W Sun, C Mao - Journal of Materials Chemistry …, 2023 - pubs.rsc.org
Peripheral nerve injury (PNI) results in persistent pain, a burning sensation, tingling, or
complete loss of sensation. Treating large nerve defects is a major challenge, and the use of …