Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Ischemia and reperfusion (IR) injury remains one of the major problems in liver surgery and
transplantation, which determines the viability of the hepatic tissue after resection and of the …

Trimetazidine (TMZ) is an effective and well‐tolerated antianginal drug that possesses
protective properties against ischemia‐induced heart injury. Growing interest in metabolic …

Background Vascular occlusion during liver resection results in ischaemia-reperfusion (IR)
injury, which can lead to liver dysfunction. We performed a systematic review and meta …

Cisplatin‐induced peripheral neuropathy (CIPN) is a common and debilitating side effect of
cisplatin chemotherapy used in cancer treatment. This study explored the neuroprotective …

Trimetazidine has no hemodynamic/antithrombotic actions. Hence, its anti-ischemic
properties have been mostly attributed to its metabolic effects. However, this issue is not …

This review highlights recent advances in our understanding of intracellular mechanisms
underlying programmed cell death in hepatic ischemia/reperfusion injury. A range of …

Liver fibrosis is a significant health complication with the potential to result in serious
mortality and morbidity. However, there is no standard treatment due to its complex …

Trimetazidine (TMZ) is a beneficial and well-tolerable anti-anginal drug which has protective
action towards ischemia and reperfusion injury. TMZ performs its anti-ischemic effect by …

Stable angina pectoris, a symptom of coronary heart disease (CHD), manifests as stress-
induced ischaemic episodes resulting in severe chest pain. Therapeutic aims are to improve …