Chemical and biophysical signatures of the protein corona in nanomedicine

J Ren, N Andrikopoulos, K Velonia… - Journal of the …, 2022 - ACS Publications
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

Nanoparticle protein corona: from structure and function to therapeutic targeting

G Bashiri, MS Padilla, KL Swingle, SJ Shepherd… - Lab on a Chip, 2023 - pubs.rsc.org
Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

Dynamic intracellular exchange of nanomaterials' protein corona perturbs proteostasis and remodels cell metabolism

R Cai, J Ren, M Guo, T Wei, Y Liu… - Proceedings of the …, 2022 - National Acad Sciences
The nanomaterial–protein “corona” is a dynamic entity providing a synthetic–natural
interface mediating cellular uptake and subcellular distribution of nanomaterials in biological …

Anti-tumor immune potentiation targets-engineered nanobiotechnologies: design principles and applications

R Jiao, X Lin, Q Zhang, Y Zhang, W Qin, Q Yang… - Progress in Materials …, 2024 - Elsevier
Combined therapeutic strategies hold promises in augmenting antigen release to enhance
anti-tumor immunity, which have garnered attention in numerous scholarly reviews. Beyond …

The Development of Chiral Nanoparticles to Target NK Cells and CD8+ T Cells for Cancer Immunotherapy

W Wang, J Zhao, C Hao, S Hu, C Chen… - Advanced …, 2022 - Wiley Online Library
The chirality of nanomaterials (nanoparticles, NPs) can influence their interaction with cells
and biological systems. However, how chirality can exert impact on the immune response …

Analysis of nanomaterial biocoronas in biological and environmental surroundings

P Zhang, M Cao, AJ Chetwynd, K Faserl… - Nature protocols, 2024 - nature.com
A biomolecular coating, or biocorona, forms on the surface of engineered nanomaterials
(ENMs) immediately as they enter biological or environmental systems, defining their …

Sustainable approach for develo** graphene-based materials from natural resources and biowastes for electronic applications

S **dal, R Anand, N Sharma, N Yadav… - ACS Applied …, 2022 - ACS Publications
Graphene, attributable to its exceptional electrical, chemical, physical, mechanical, thermal,
structural, and optical characteristics, has evolved into a remarkable and revolutionary …

Transcytosis-enabled active extravasation of tumor nanomedicine

Q Zhou, J Li, J **ang, S Shao, Z Zhou, J Tang… - Advanced Drug Delivery …, 2022 - Elsevier
Extravasation is the first step for nanomedicines in circulation to reach targeted solid tumors.
Traditional nanomedicines have been designed to extravasate into tumor interstitium …

[HTML][HTML] Understanding the bidirectional interactions between two-dimensional materials, microorganisms, and the immune system

G Peng, B Fadeel - Advanced drug delivery reviews, 2022 - Elsevier
Abstract Two-dimensional (2D) materials such as the graphene-based materials, transition
metal dichalcogenides, transition metal carbides and nitrides (MXenes), black phosphorus …

A chiral fluorescent Ir (iii) complex that targets the GPX4 and ErbB pathways to induce cellular ferroptosis

X Zhao, J Zhang, W Zhang, Z Guo, W Wei, X Wang… - Chemical …, 2023 - pubs.rsc.org
Ferroptosis has recently emerged as a non-apoptotic form of programmed cell death and
promising target for anticancer treatment. However, it is challenging to discover ferroptosis …