Cancer is a neoplastic disease that remains a global challenge with a reported prevalence
that is increasing annually. Though existing drugs can be applied as single or combined …

Alpha-amylase is widely exploited as a drug target for preventing postprandial
hyperglycemia in diabetes and other metabolic diseases. Inhibition of this enzyme by plant …

This study is aimed at evaluating the anti-proliferative activity of a novel hydroxyflavone
isolated for the first time from Kigelia africana fruit, against cervical cancer (HeLa) and …

Kigelia africana herbal products are often used traditionally to treat erectile dysfunction and
other sexual complaints, but the underlying mechanism is not yet understood. This study …

Breast and prostate cancer holds the position of foremost contributors to mortality. Dietary
therapies for accompanied by medication are widely recognized as a potential method to …

Aldose reductase and glycogen synthase kinase 3β (GSK3β) represent two of the ideal drug
targets in diabetes due to their role in the pathogenesis of diabetes. Studies have shown that …

A mutant P53 protein plays such a crucial role in ovarian cancer, and natural compounds
have been known to be effective in treating cancer. The current study was conducted to …

Abstract Motivation Investigating novel Drug-target interactions is crucial for expanding the
chemical space of emerging therapeutic targets in human diseases. Herein, we explored the …

Protein tyrosine phosphatase 1B (PTP1B) has been identified as a promising drug target for
the development of diabetes medications via an inhibition mechanism. Using a …

African indigenous herbs and medicinal plants are extensively reported for their protective
and therapeutic potential against Diabetes. However, most of the constituent phytochemicals …