The blood-brain barrier (BBB) is a physical and biochemical barrier that precisely controls
cerebral homeostasis. It also plays a central role in the regulation of blood-to-brain flux of …

Sepsis-associated cerebral dysfunction is complex pathophysiology, generated from primary
infections that are developed elsewhere in the body. The neonates, elderly population and …

The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Monocarboxylate transporters (MCTs) are known to mediate the transport of short chain
monocarboxylates such as lactate, pyruvate and butyrate. Currently, fourteen members of …

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as
statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary …

Background: The blood–brain barrier acts as a highly regulated interface; its dysfunction
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …

The aged dog naturally develops cognitive decline in many different domains (including
learning and memory) but also exhibits human-like individual variability in the aging …

Modulation of endogenous cellular defense mechanisms via the vitagene system represents
an innovative approach to therapeutic intervention in diseases causing chronic tissue …

The blood-brain barrier (BBB) is a critical regulator of brain homeostasis. Additionally, the
BBB is the most significant obstacle to effective CNS drug delivery. It possesses specific …

Background: Statins represent a class of medications widely prescribed to efficiently treat
dyslipidemia. These drugs inhibit 3-βhydroxy 3β-methylglutaryl Coenzyme A reductase …