A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in
diverse organisms. Here we review findings from budding and fission yeasts that reveal both …

Cells live in a chemical environment and are able to orient towards chemical cues.
Unicellular haploid fungal cells communicate by secreting pheromones to reproduce …

Mathematical modeling has been instrumental in identifying common principles of cell
polarity across diverse systems. These principles include positive feedback loops that are …

Mitogen-activated protein kinase (MAPK) pathways are conserved from yeast to man and
regulate a variety of cellular processes, including proliferation and differentiation. Recent …

Cell polarity is fundamental to the function of most cells. The evolutionarily conserved
molecular machinery that controls cell polarity is centered on a family of GTPases related to …

Accurate decoding of spatial chemical landscapes is critical for many cell functions.
Eukaryotic cells decode local chemical gradients to orient growth or movement in productive …

Fungi exhibit an enormous variety of morphologies, including yeast colonies, hyphal
mycelia, and elaborate fruiting bodies. This diversity arises through a combination of polar …

In response to pheromone Saccharomyces cerevisiae extend a mating projection. This
process depends on the formation of polarized actin cables which direct secretion to the …

How small eukaryotic cells can interpret dynamic, noisy, and spatially complex chemical
gradients to orient growth or movement is poorly understood. We address this question …

Accurate detection of extracellular chemical gradients is essential for many cellular
behaviors. Gradient sensing is challenging for small cells, which can experience little …