Circulating cell-free nucleic acids: main characteristics and clinical application

M Szilágyi, O Pös, É Márton, G Buglyó… - International journal of …, 2020 - mdpi.com
Liquid biopsy recently became a very promising diagnostic method that has several
advantages over conventional invasive methods. Liquid biopsy may serve as a source of …

Current and future clinical applications of ctDNA in immuno-oncology

JC Stadler, Y Belloum, B Deitert, M Sementsov… - Cancer Research, 2022 - AACR
Testing peripheral blood for circulating tumor DNA (ctDNA) offers a minimally invasive
opportunity to diagnose, characterize, and monitor the disease in individual cancer patients …

[HTML][HTML] Liquid biopsy approaches to capture tumor evolution and clinical outcomes during cancer immunotherapy

L Sivapalan, JC Murray, JVL Canzoniero… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Circulating cell-free tumor DNA (ctDNA) can serve as a real-time biomarker of tumor burden
and provide unique insights into the evolving molecular landscape of cancers under the …

Current and emerging applications of droplet digital PCR in oncology: an updated review

S Olmedillas-López, R Olivera-Salazar… - Molecular Diagnosis & …, 2022 - Springer
In the era of personalized medicine and targeted therapies for the management of patients
with cancer, ultrasensitive detection methods for tumor genoty**, such as next-generation …

Current perspectives on circulating tumor DNA, precision medicine, and personalized clinical management of cancer

KCS Oliveira, IB Ramos, JMC Silva, WF Barra… - Molecular Cancer …, 2020 - AACR
Circulating tumor DNA (ctDNA) has recently emerged as a minimally invasive “liquid biopsy”
tool in precision medicine. ctDNA-genomic DNA fragments that are released into the …

[HTML][HTML] Recent advances in circulating nucleic acids in oncology

A Otandault, P Anker, ZAA Dache, V Guillaumon… - Annals of …, 2019 - Elsevier
Circulating cell-free DNA (cfDNA) is one of the fastest growing and most exciting areas in
oncology in recent years. Its potential clinical uses cover now each phase of cancer patient …

[HTML][HTML] Immunotherapy in melanoma: Can we predict response to treatment with circulating biomarkers?

E Splendiani, ZM Besharat, A Covre, M Maio… - Pharmacology & …, 2024 - Elsevier
Melanoma is the most aggressive form of skin cancer, representing approximately 4% of all
cutaneous neoplasms it accounts for up to 80% of deaths. Advanced stages of melanoma …

[HTML][HTML] Circulating tumour DNA (ctDNA) in metastatic melanoma, a systematic review and meta-analysis

L Gracie, Y Pan, EG Atenafu, DG Ward, M Teng… - European Journal of …, 2021 - Elsevier
Abstract Introduction: Circulating tumour DNA (ctDNA) is an emerging biomarker in
melanoma. We performed a systematic review and meta-analysis to explore its clinical utility …

Precision medicine and melanoma: multi-omics approaches to monitoring the immunotherapy response

F Valenti, I Falcone, S Ungania, F Desiderio… - International journal of …, 2021 - mdpi.com
The treatment and management of patients with metastatic melanoma have evolved
considerably in the “era” of personalized medicine. Melanoma was one of the first solid …

ctDNA response after pembrolizumab in non-small cell lung cancer: phase 2 adaptive trial results

V Anagnostou, C Ho, G Nicholas, RA Juergens… - Nature medicine, 2023 - nature.com
Circulating tumor DNA (ctDNA) has shown promise in capturing primary resistance to
immunotherapy. BR. 36 is a multi-center, randomized, ctDNA-directed, phase 2 trial of …