Cell type-specific roles of NF-κB linking inflammation and thrombosis
M Mussbacher, M Salzmann, C Brostjan… - Frontiers in …, 2019 - frontiersin.org
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
Adipose tissue in obesity‐related inflammation and insulin resistance: cells, cytokines, and chemokines
K Makki, P Froguel, I Wolowczuk - … Scholarly Research Notices, 2013 - Wiley Online Library
Adipose tissue is a complex organ that comprises a wide range of cell types with diverse
energy storage, metabolic regulation, and neuroendocrine and immune functions. Because …
energy storage, metabolic regulation, and neuroendocrine and immune functions. Because …
[HTML][HTML] Genome-wide map** of HATs and HDACs reveals distinct functions in active and inactive genes
Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to
control histone acetylation. As acetylation is a histone mark for active transcription, HATs …
control histone acetylation. As acetylation is a histone mark for active transcription, HATs …
Circuitry of nuclear factor κB signaling
A Hoffmann, D Baltimore - Immunological reviews, 2006 - Wiley Online Library
Over the past few years, the transcription factor nuclear factor (NF)‐κB and the proteins that
regulate it have emerged as a signaling system of pre‐eminent importance in human …
regulate it have emerged as a signaling system of pre‐eminent importance in human …
The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice
W Tang, Y Lu, QY Tian, Y Zhang, FJ Guo, GY Liu… - Science, 2011 - science.org
The growth factor progranulin (PGRN) has been implicated in embryonic development,
tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We …
tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We …
A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors
DJ Konieczkowski, CM Johannessen, O Abudayyeh… - Cancer discovery, 2014 - AACR
Most melanomas harbor oncogenic BRAFV600 mutations, which constitutively activate the
MAPK pathway. Although MAPK pathway inhibitors show clinical benefit in BRAFV600 …
MAPK pathway. Although MAPK pathway inhibitors show clinical benefit in BRAFV600 …
Interleukin-7 receptor expression: intelligent design
R Mazzucchelli, SK Durum - Nature Reviews Immunology, 2007 - nature.com
Abstract Interleukin-7 (IL-7) is produced by stromal cells in lymphoid tissues and is required
for the development of T cells and for their persistence in the periphery. Unlike many other …
for the development of T cells and for their persistence in the periphery. Unlike many other …
The NF-κB regulatory network
AR Brasier - Cardiovascular toxicology, 2006 - Springer
Nuclear factor (NF)-κB is a family of seven structurally related transcription factors that play a
central role in cardiovascular growth, stress response, and inflammation by controlling gene …
central role in cardiovascular growth, stress response, and inflammation by controlling gene …
Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37
N Mookherjee, KL Brown, DME Bowdish… - The Journal of …, 2006 - journals.aai.org
The sole human cathelicidin peptide, LL-37, has been demonstrated to protect animals
against endotoxemia/sepsis. Low, physiological concentrations of LL-37 (≤ 1 μg/ml) were …
against endotoxemia/sepsis. Low, physiological concentrations of LL-37 (≤ 1 μg/ml) were …
Inferring pathway activity toward precise disease classification
The advent of microarray technology has made it possible to classify disease states based
on gene expression profiles of patients. Typically, marker genes are selected by measuring …
on gene expression profiles of patients. Typically, marker genes are selected by measuring …