Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Valproic acid (VPA) is a very effective anticonvulsant and mood stabilizer with relatively few
side effects. Being an epigenetic modulator, it undergoes clinical trials for the treatment of …

Valproic acid, a branching short chain fatty acid, is a popular drug to treat epilepsy and acts
as a mood-stabilizing drug. The obstruction of ion channels and Gamma Amino Butyrate …

Glaucoma is the leading cause of irreversible blindness globally. The disease causes vision
loss due to neurodegeneration of the retinal ganglion cell (RGC) projection to the brain …

Evidence suggests a role for low-grade inflammation and oxidative stress in the
pathophysiology of bipolar disorder. We conducted a systematic review and meta-analysis …

Objectives People with bipolar disorder have an elevated risk of mortality. This study
evaluated associations between the use of mood stabilizers and the risks of all‐cause …

Accumulating evidence indicates a central role for epigenetic modifications in the
progression of stroke pathology. These epigenetic mechanisms are involved in complex and …

Beyond its use as an antiepileptic drug, over time valproate has been increasingly used for
several other therapeutic applications. Among these, the antineoplastic effects of valproate …

An estimated 60 million people worldwide suffer from epilepsy, half of whom are women.
About one-third of women with epilepsy are of childbearing age. The childbirth rate in …

Glioblastoma (GBM) is a lethal cancer characterized by hypervascularity and necrosis
associated with hypoxia. Here, it is found that hypoxia preferentially induces the actin …