Protein corona: a new approach for nanomedicine design

VH Nguyen, BJ Lee - International journal of nanomedicine, 2017 - Taylor & Francis
After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is
formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction …

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

E Fröhlich - International journal of nanomedicine, 2012 - Taylor & Francis
Many types of nanoparticles (NPs) are tested for use in medical products, particularly in
imaging and gene and drug delivery. For these applications, cellular uptake is usually a …

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

CD Walkey, WCW Chan - Chemical Society Reviews, 2012 - pubs.rsc.org
Nanomaterials hold promise as multifunctional diagnostic and therapeutic agents. However,
the effective application of nanomaterials is hampered by limited understanding and control …

The evolution of the protein corona around nanoparticles: a test study

M Lundqvist, J Stigler, T Cedervall, T Berggard… - ACS …, 2011 - ACS Publications
The importance of the protein corona formed around nanoparticles upon entering a
biological fluid has recently been highlighted. This corona is, when sufficiently long-lived …

Particle shape enhances specificity of antibody-displaying nanoparticles

S Barua, JW Yoo, P Kolhar… - Proceedings of the …, 2013 - National Acad Sciences
Monoclonal antibodies are used in numerous therapeutic and diagnostic applications;
however, their efficacy is contingent on specificity and avidity. Here, we show that …

Preformed albumin corona, a protective coating for nanoparticles based drug delivery system

Q Peng, S Zhang, Q Yang, T Zhang, XQ Wei, L Jiang… - Biomaterials, 2013 - Elsevier
The non-specific interaction between nanoparticles (NPs) and plasma proteins occurs
immediately after NPs enter the blood, resulting in the formation of the protein corona that …

Nanoparticle–blood interactions: the implications on solid tumour targeting

J Lazarovits, YY Chen, EA Sykes… - Chemical …, 2015 - pubs.rsc.org
Nanoparticles are suitable platforms for cancer targeting and diagnostic applications.
Typically, less than 10% of all systemically administered nanoparticles accumulate in the …

Biosafety and bioapplication of nanomaterials by designing protein–nanoparticle interactions

ST Yang, Y Liu, YW Wang, A Cao - Small, 2013 - Wiley Online Library
The protein–nanoparticle (NP) interface is a current frontier of multiple disciplines, full of
challenges and opportunities. The unique behaviors of nanomaterials (NMs) bring many …

[HTML][HTML] The uptake of PLGA micro or nanoparticles by macrophages provokes distinct in vitro inflammatory response

R Nicolete, DF dos Santos, LH Faccioli - International …, 2011 - Elsevier
Biodegradable micro/nanoparticles generated from PLGA have recently attracted attention
due to their clinically proven biocompatibility, especially for immunization purposes. These …

Silver nanoparticle protein corona composition in cell culture media

JH Shannahan, X Lai, PC Ke, R Podila, JM Brown… - PloS one, 2013 - journals.plos.org
The potential applications of nanomaterials as drug delivery systems and in other products
continue to expand. Upon introduction into physiological environments and driven by …