Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It
has a poor response to conventional therapy and has an extremely poor 5-year survival rate …

Pancreatic cancer is an aggressive cancer with a poor prognosis. Metabolic abnormalities
are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to …

Lipid signaling is defined as any biological signaling action in which a lipid messenger
binds to a protein target, converting its effects to specific cellular responses. In this complex …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplasia,
characterized by early metastasis, low diagnostic rates at early stages, resistance to drugs …

Simple Summary The PI3K/AKT pathway is one of the most important signaling nodes in
cancer. While class I PI3K roles in cancer are well known, class II and III functions in …

Circular RNAs (circRNA) contribute to cancer stemness, proliferation, and metastasis. The
biogenesis of circRNAs can be impacted by the genetic landscape of tumors. Herein, we …

The incidence of pancreatic cancer is increasing in both developed and develo** Nations.
In recent years, various research evidence suggested that reprogrammed metabolism may …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies with
insidious initiation and early metastasis. The autonomous reprogramming of amino acid …

Pancreatic cancer is a lethal disease with limited effective treatments. A deeper
understanding of its molecular mechanisms is crucial to reduce incidence and mortality …

Pancreatic malignancy is the fourth cause of cancer-related death in Western countries and
is predicted to become the second leading cause of cancer-related mortality by 2030. The …