Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

C Liao, X Huang, Q Wang, D Yao, W Lu - Frontiers in cellular and …, 2022 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial infections in
severely ill and immunocompromised patients. Ubiquitously disseminated in the …

Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

Cryo-EM structure of a type IV secretion system

K Macé, AK Vadakkepat, A Redzej, N Lukoyanova… - Nature, 2022 - nature.com
Bacterial conjugation is the fundamental process of unidirectional transfer of DNAs, often
plasmid DNAs, from a donor cell to a recipient cell. It is the primary means by which …

Bacterial secretion systems: an overview

ER Green, J Mecsas - Virulence mechanisms of bacterial …, 2016 - Wiley Online Library
One essential prokaryotic cell function is the transport of proteins from the cytoplasm into
other compartments of the cell, the environment, and/or other bacteria or eukaryotic cells—a …

Biogenic Synthesis of Silver Nanoparticles Using Phyllanthus emblica Fruit Extract and Its Inhibitory Action Against the Pathogen Acidovorax oryzae Strain RS-2 of …

MMI Masum, MM Siddiqa, KA Ali, Y Zhang… - Frontiers in …, 2019 - frontiersin.org
Biogenic synthesis of silver nanoparticles (AgNPs) using plants has become a promising
substitute to the conventional chemical synthesis method. In this study, we report low-cost …

Secretion systems in Gram-negative bacteria: structural and mechanistic insights

TRD Costa, C Felisberto-Rodrigues, A Meir… - Nature Reviews …, 2015 - nature.com
Bacteria have evolved a remarkable array of sophisticated nanomachines to export various
virulence factors across the bacterial cell envelope. In recent years, considerable progress …

The Type VI secretion system: a versatile bacterial weapon

S Coulthurst - Microbiology, 2019 - microbiologyresearch.org
The Type VI secretion system (T6SS) is a protein nanomachine that is widespread in Gram-
negative bacteria and is used to translocate effector proteins directly into neighbouring cells …

Understanding competition and cooperation within the mammalian gut microbiome

KZ Coyte, S Rakoff-Nahoum - Current Biology, 2019 - cell.com
The mammalian gut harbors a vast community of microorganisms—termed the microbiota—
whose composition and dynamics are considered to be critical drivers of host health. These …

Aim, load, fire: the type VI secretion system, a bacterial nanoweapon

FR Cianfanelli, L Monlezun, SJ Coulthurst - Trends in microbiology, 2016 - cell.com
Bacteria utilise specialised protein secretion systems to interact with host organisms,
competitor bacteria, and the environment. The Type VI secretion system (T6SS) is a versatile …

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

K Xu, P Acharya, R Kong, C Cheng, GY Chuang… - Nature medicine, 2018 - nature.com
A central goal of HIV-1 vaccine research is the elicitation of antibodies capable of
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …