Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life.
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …

Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic
alterations of CD4+ T cells through unclear mechanisms with undefined consequences. We …

Metabolic processes play a critical role in immune regulation. Metabolomics is the
systematic analysis of small molecules (metabolites) in organisms or biological samples …

The gastrointestinal mucosa is critical for maintaining the integrity and functions of the gut.
Disruption of this barrier is a hallmark and a risk factor for many intestinal and chronic …

Spontaneous control of HIV infection has been repeatedly linked to antiviral CD8+ T cells
but is not always permanent. To address mechanisms of durable and aborted control of …

Immunometabolism has been the focus of extensive research over the last years, especially
in terms of augmenting anti-tumor immune responses. Regulatory T cells (Tregs) are a …

Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART)
interruption are urgently needed. Such biomarkers can improve the safety of analytic …

The human immunodeficiency virus (HIV) infection of the immune cells expressing the
cluster of differentiation 4 cell surface glycoprotein (CD4+ cells) causes progressive decline …

The progressive decline of CD8+ cytotoxic T cells in human immunodeficiency virus (HIV)-
infected patients due to infection-triggered cell exhaustion and cell death is significantly …