Computational tools for cellular scale biophysics
Mathematical models are indispensable for disentangling the interactions through which
biological components work together to generate the forces and flows that position, mix, and …
biological components work together to generate the forces and flows that position, mix, and …
Cytoplasmic stirring by active carpets
Large cells often rely on cytoplasmic flows for intracellular transport, maintaining
homeostasis, and positioning cellular components. Understanding the mechanisms of these …
homeostasis, and positioning cellular components. Understanding the mechanisms of these …
Twist and turn: elastohydrodynamics of microscale active fibres
M Lisicki - The European Physical Journal Special Topics, 2024 - Springer
Cellular locomotion often involves the motion of thin, elastic filaments, such as cilia and
flagella, in viscous environments. The manuscript serves as a general introduction to the …
flagella, in viscous environments. The manuscript serves as a general introduction to the …
Series solution and its extension for the nonlinear flow response of soft hair beds
BH Sun, B Pang, M Li - Physics of Fluids, 2024 - pubs.aip.org
In nature and engineering applications, flexible fiber beds covering biological surfaces can
play a role in reducing resistance. These fibers deform under the action of fluids, and this …
play a role in reducing resistance. These fibers deform under the action of fluids, and this …
Geometric model for dynamics of motor-driven centrosomal asters
The centrosomal aster is a mobile and adaptable cellular organelle that exerts and transmits
forces necessary for tasks such as nuclear migration and spindle positioning. Recent …
forces necessary for tasks such as nuclear migration and spindle positioning. Recent …
A simulation platform for slender, semiflexible, and inextensible fibers with Brownian hydrodynamics and steric repulsion
The last few years have witnessed an explosion of new numerical methods for filament
hydrodynamics. Aside from their ubiquity in biology, physics, and engineering, filaments …
hydrodynamics. Aside from their ubiquity in biology, physics, and engineering, filaments …
[PDF][PDF] Swirling Instability Mediated by Elastic and Hydrodynamic Couplings in Cytoplasmic Streaming
T Ishikawa, T Torisawa, H Wada, A Kimura - PRX Life, 2025 - APS
Cytoplasmic streaming is driven by molecular motors that move along the cytoskeleton and
entrain the surrounding fluid. In certain cell types, the direction of cytoplasmic streaming is …
entrain the surrounding fluid. In certain cell types, the direction of cytoplasmic streaming is …
A first-principles geometric model for dynamics of motor-driven centrosomal asters
The centrosomal aster is a mobile and adaptable cellular organelle that exerts and transmits
forces necessary for tasks such as nuclear migration and spindle positioning. Recent …
forces necessary for tasks such as nuclear migration and spindle positioning. Recent …
Flows, self-organization, and transport in living cells
MJ Shelley - Physical Review Fluids, 2024 - APS
This paper briefly reprises, with added commentary, a talk I gave on transport and flows
within living cells at an APS-DFD meeting. Directed transport is especially important in large …
within living cells at an APS-DFD meeting. Directed transport is especially important in large …
Mechanics of spindle orientation in human mitotic cells is determined by pulling forces on astral microtubules and clustering of cortical dynein
The forces that orient the spindle in human cells remain poorly understood due to a lack of
direct mechanical measurements in mammalian systems. We use magnetic tweezers to …
direct mechanical measurements in mammalian systems. We use magnetic tweezers to …