Association methods based on linkage disequilibrium (LD) offer a promising approach for
detecting genetic variations that are responsible for complex human diseases. Although …

Prior to performance of linkage analysis, elimination of all Mendelian inconsistencies in the
pedigree data is essential. Often, identification of erroneous genotypes by visual inspection …

Statistical methods for genome-wide association studies (GWAS) continue to improve.
However, the increasing volume and variety of genetic and genomic data make …

Isolated or nonsyndromic cleft lip with or without cleft palate (CL/P) is a common birth defect
with a complex etiology. A 10-cM genome scan of 388 extended multiplex families with CL/P …

Terminal keratinocyte differentiation involves coordinated expression of several functionally
interdependent genes, many of which have been mapped to the epidermal differentiation …

After a genomewide screen in the Hutterites was completed, the IL4RA gene was examined
as the 16p-linked susceptibility locus for asthma and atopy. Seven known variants and one …

Here we report the first genome-wide scan performed for caries. Evidence from twin studies
suggests a genetic component to caries. We aimed to identify genetic factors contributing to …

Juvenile-onset cataracts are distinguished from congenital cataracts by the initial clarity of
the lens at birth and the gradual development of lens opacity in the second and third …

Motivation: Haplotype reconstruction is an essential step in genetic linkage and association
studies. Although many methods have been developed to estimate haplotype frequencies …

We revisited 46 families with two or more siblings affected with an orofacial cleft that
participated in previous genome wide studies and collected complete dental information …