Multiscale computational modeling of vascular adaptation: a systems biology approach using agent-based models
The widespread incidence of cardiovascular diseases and associated mortality and
morbidity, along with the advent of powerful computational resources, have fostered an …
morbidity, along with the advent of powerful computational resources, have fostered an …
A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics
In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …
Uncertainty quantification of a three-dimensional in-stent restenosis model with surrogate modelling
In-stent restenosis is a recurrence of coronary artery narrowing due to vascular injury
caused by balloon dilation and stent placement. It may lead to the relapse of angina …
caused by balloon dilation and stent placement. It may lead to the relapse of angina …
[HTML][HTML] Multiscale computing in the exascale era
We expect that multiscale simulations will be one of the main high performance computing
workloads in the exascale era. We propose multiscale computing patterns as a generic …
workloads in the exascale era. We propose multiscale computing patterns as a generic …
Computational modeling of in-stent restenosis: Pharmacokinetic and pharmacodynamic evaluation
Persistence of the pathology of in-stent restenosis even with the advent of drug-eluting
stents warrants the development of highly resolved in silico models. These computational …
stents warrants the development of highly resolved in silico models. These computational …
[HTML][HTML] An intricate interplay between stent drug dose and release rate dictates arterial restenosis
Since the introduction of percutaneous coronary intervention (PCI) for the treatment of
obstructive coronary artery disease (CAD), patient outcomes have progressively improved …
obstructive coronary artery disease (CAD), patient outcomes have progressively improved …
Potential mechanisms of in-stent neointimal atherosclerotic plaque formation
DM Zhang, SL Chen - Journal of Cardiovascular Pharmacology, 2021 - journals.lww.com
Percutaneous coronary intervention has become the main revascularization strategy for
coronary artery disease. Compared with early percutaneous coronary angioplasty and the …
coronary artery disease. Compared with early percutaneous coronary angioplasty and the …
Multiscale agent-based modeling of restenosis after percutaneous transluminal angioplasty: effects of tissue damage and hemodynamics on cellular activity
Background Restenosis following percutaneous transluminal angioplasty (PTA) in femoral
arteries is a major cause of failure of the revascularization procedure. The arterial wall …
arteries is a major cause of failure of the revascularization procedure. The arterial wall …
A Comparison of Fully-Coupled 3D In-Stent Restenosis Simulations to In-vivo Data
We describe our fully-coupled 3D multiscale model of in-stent restenosis, with blood flow
simulations coupled to smooth muscle cell proliferation, and report results of numerical …
simulations coupled to smooth muscle cell proliferation, and report results of numerical …
An investigation of damage mechanisms in mechanobiological models of in-stent restenosis
The mechanisms behind in-stent restenosis, the re-narrowing of a stented artery, are poorly
understood. However it is known that mechanical damage due to stent implantation plays a …
understood. However it is known that mechanical damage due to stent implantation plays a …