Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

There is accumulating evidence to implicate the importance of N-methyl-d-aspartate (NMDA)
receptors to the induction and maintenance of central sensitization during pain states …

Neuropathic pain (NP) is a chronic condition that results from a lesion or disease of the
nervous system, greatly impacting patients' quality of life. Current pharmacotherapy options …

Since ketamine was approved by the FDA as an intravenous anesthetic, it has been in
clinical use for more than 50 years. Apart from its anesthetic effects, ketamine is one of the …

Despite abundant evidence implicating the importance of N‐methyl‐d‐aspartate (NMDA)
receptors in the spinal cord for pain transmission, the signal transduction coupled to NMDA …

Dendritic morphology determines many aspects of neuronal function, including action
potential propagation and information processing. However, the question remains as to how …

Activity-dependent changes in neurons of the rat superficial dorsal horn are crucial for the
induction and maintenance of neuropathic and inflammatory pain states. To identify the …

Background and purpose: Post‐synaptic density protein 95 (PSD95) contains three
PSD95/Dosophilia disc large/ZO‐1 homology domains and links neuronal nitric oxide …

Peripheral inflammation or nerve injury induces a primary afferent barrage into the spinal
cord, which can cause N-methyl D-aspartate (NMDA) receptor-dependent alterations in the …

Chronic pain due to nerve injury is resistant to current analgesics. Animal models of
neuropathic pain show neuronal plasticity and behavioral reflex sensitization in the spinal …