Therapeutic outcomes of isatin and its derivatives against multiple diseases: Recent developments in drug discovery
Isatin (1 H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in
humans and different plants. The isatin nucleus and its derivatives are owed the attention of …
humans and different plants. The isatin nucleus and its derivatives are owed the attention of …
Isatin derivatives with potential antitubercular activities
D Jiang, GQ Wang, X Liu, Z Zhang… - Journal of …, 2018 - Wiley Online Library
Tuberculosis is a life‐threatening chronic infectious disease, which primarily affects the
lungs but can spread to other vital organs. The re‐emergence and wide spread of new …
lungs but can spread to other vital organs. The re‐emergence and wide spread of new …
Design and synthesis of heterocyclic azole based bioactive compounds: Molecular structures, quantum simulation, and mechanistic studies through docking as multi …
Abstract Two heterocyclic azole compounds, 3-(2, 3-dihydrobenzo [d] thiazol-2-yl)-4H-
chromen-4-one (SVS1) and 5-(1H-indol-3-yl)-4-methyl-2, 4-dihydro-3H-1, 2, 4-triazole-3 …
chromen-4-one (SVS1) and 5-(1H-indol-3-yl)-4-methyl-2, 4-dihydro-3H-1, 2, 4-triazole-3 …
Synthesis, structural elucidation, DFT investigations, biological evaluation and molecular docking studies of tetraamide-based macrocyclic cobalt (II) complexes
A new series of 16–18 membered cobalt (II) macrocyclic complexes derived by 3, 4-
diaminobenzophenone have been synthesized. The elemental analysis, FT-IR, 1H NMR …
diaminobenzophenone have been synthesized. The elemental analysis, FT-IR, 1H NMR …
Nickel (II) bis (isatin thiosemicarbazone) complexes induced apoptosis through mitochondrial signaling pathway and G0/G1 cell cycle arrest in IM-9 cells
Abstract Three novel complexes (1, 3 and 4) ligating N-substituted isatin thiosemicarbazone
derivatives have been synthesized and their structural and biological characteristics have …
derivatives have been synthesized and their structural and biological characteristics have …
Synthesis of Ni (II) complexes bearing indole-based thiosemicarbazone ligands for interaction with biomolecules and some biological applications
A series of new Ni (II) complexes containing indole-based thiosemicarbazone ligands was
synthesized and characterized by elemental analyses, and UV–visible, FT-IR, 1 H & 13 C …
synthesized and characterized by elemental analyses, and UV–visible, FT-IR, 1 H & 13 C …
Copper, nickel and zinc complexes of 3-acetyl coumarin thiosemicarbazone: Synthesis, characterization and in vitro evaluation of cytotoxicity and DNA/protein binding …
A new 3-acetylcoumarin thiosemicarbazone (AcTsc) and its copper (II)(1), nickel (II)(2) and
zinc (II)(3) complexes were synthesized and characterized by elemental analysis, UV–Vis …
zinc (II)(3) complexes were synthesized and characterized by elemental analysis, UV–Vis …
Synthesis, structural characterization, thermal analysis, DFT, biocidal evaluation and molecular docking studies of amide-based Co (II) complexes
Many distinct amino acid and aromatic amine-derived transition metal complexes are used
as physiologically active compounds. A few Cobalt (II) complexes have been synthesized by …
as physiologically active compounds. A few Cobalt (II) complexes have been synthesized by …
Design, Synthesis, characterization and biological screening of novel thiosemicarbazones and their derivatives with Potent Antibacterial and Antidiabetic Activities
Thiosemicarbazones and their derivatives were synthesized by reacting carbonyl
compounds with thiosemicarbazide, followed by treatment with metal salts. The prepared …
compounds with thiosemicarbazide, followed by treatment with metal salts. The prepared …
Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents
In recent years, cell cycle and checkpoint pathways regulation are offering new therapeutic
approaches against cancer. Isatin, is a well exploited scaffold in the anticancer domain …
approaches against cancer. Isatin, is a well exploited scaffold in the anticancer domain …