Computational models in cardiology
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
Evolution of strategies to improve preclinical cardiac safety testing
G Gintant, PT Sager, N Stockbridge - Nature reviews Drug discovery, 2016 - nature.com
The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …
advance novel drug candidates. This article discusses evolving mechanistically based …
Discovery of asciminib (ABL001), an allosteric inhibitor of the tyrosine kinase activity of BCR-ABL1
J Schoepfer, W Jahnke, G Berellini, S Buonamici… - 2018 - ACS Publications
Chronic myelogenous leukemia (CML) arises from the constitutive activity of the BCR-ABL1
oncoprotein. Tyrosine kinase inhibitors (TKIs) that target the ATP-binding site have …
oncoprotein. Tyrosine kinase inhibitors (TKIs) that target the ATP-binding site have …
Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity
Early prediction of cardiotoxicity is critical for drug development. Current animal models
raise ethical and translational questions, and have limited accuracy in clinical risk prediction …
raise ethical and translational questions, and have limited accuracy in clinical risk prediction …
[HTML][HTML] The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on IK1
B Goversen, MAG van der Heyden… - Pharmacology & …, 2018 - Elsevier
Preclinical drug screens are not based on human physiology, possibly complicating
predictions on cardiotoxicity. Drug screening can be humanised with in vitro assays using …
predictions on cardiotoxicity. Drug screening can be humanised with in vitro assays using …
Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment
Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many
drugs from the market and is therefore of major concern to global regulatory agencies and …
drugs from the market and is therefore of major concern to global regulatory agencies and …
Human induced pluripotent stem cell (hiPSC)-derived cells to assess drug cardiotoxicity: opportunities and problems
Billions of US dollars are invested every year by the pharmaceutical industry in drug
development, with the aim of introducing new drugs that are effective and have minimal side …
development, with the aim of introducing new drugs that are effective and have minimal side …
[HTML][HTML] Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?
Cardiac electrophysiology models have been developed for over 50 years, and now include
detailed descriptions of individual ion currents and sub-cellular calcium handling. It is …
detailed descriptions of individual ion currents and sub-cellular calcium handling. It is …
Modeling the electrophysiological properties of the infarct border zone
Ventricular arrhythmias (VA) in patients with myocardial infarction (MI) are thought to be
associated with structural and electrophysiological remodeling within the infarct border zone …
associated with structural and electrophysiological remodeling within the infarct border zone …