Laboratory rodent housing often fails to meet rodents' behavioral and physiological needs.
We previously found that compared to well-resourced (often called 'enriched') housing …

This review article delves into the details of the 3R-Refinement principles as a vital
framework for ethically sound rodent research laboratory. It highlights the core objective of …

The 3Rs principle of replacing, reducing and refining the use of animals in science has been
gaining widespread support in the international research community and appears in …

Improving the predictive power of mouse models | Nature Biotechnology Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for …

Organisms must regulate their behavior flexibly in the face of environmental challenges.
Failure can lead to a host of maladaptive behavioral traits associated with a range of …

Boredom is an aversive mental state that is typically evoked by monotony and drives
individuals to seek novel information. Despite this effect on individual behavior, the …

As scientific advancements continue to reshape the world, it becomes increasingly crucial to
uphold ethical standards and minimize the potentially adverse impact of research activities …

Conventional housing for laboratory mice limits the expression of species-specific
behaviours and restricts the control over their environment, thus failing to guarantee the …

Simple Summary Continued evolution of how research animals are kept and cared for is
vital for respecting the 3Rs of replacement, reduction, and refinement. How animals feel …

Feed wastage in laboratory mice, also known as chewing or grinding behavior, is
problematic for program management and animal welfare. The destruction of pelleted feed …