Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Pharmacogenomics in the clinic
MV Relling, WE Evans - Nature, 2015 - nature.com
After decades of discovery, inherited variations have been identified in approximately 20
genes that affect about 80 medications and are actionable in the clinic. And some …
genes that affect about 80 medications and are actionable in the clinic. And some …
The OncoArray Consortium: a network for understanding the genetic architecture of common cancers
Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …
[HTML][HTML] Response and toxicity to cytarabine therapy in leukemia and lymphoma: from dose puzzle to pharmacogenomic biomarkers
R Di Francia, S Crisci, A De Monaco, C Cafiero, A Re… - Cancers, 2021 - mdpi.com
Simple Summary In this review, the authors propose a crosswise examination of cytarabine-
related issues ranging from the spectrum of clinical activity and severe toxicities, through …
related issues ranging from the spectrum of clinical activity and severe toxicities, through …
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer
Anthracyclines are used in over 50% of childhood cancer treatment protocols, but their
clinical usefulness is limited by anthracycline-induced cardiotoxicity (ACT) manifesting as …
clinical usefulness is limited by anthracycline-induced cardiotoxicity (ACT) manifesting as …
Aetiology, genetics and prevention of secondary neoplasms in adult cancer survivors
LB Travis, WD Wahnefried, JM Allan… - Nature reviews Clinical …, 2013 - nature.com
Second and higher-order malignancies now comprise about 18% of all incident cancers in
the USA, superseding first primary cancers of the breast, lung, and prostate. The occurrence …
the USA, superseding first primary cancers of the breast, lung, and prostate. The occurrence …
[HTML][HTML] Cancer: An unknown territory; rethinking before going ahead
A Upadhyay - Genes & diseases, 2021 - Elsevier
Cancer is a disease of altered signaling and metabolism, causing uncontrolled division and
survival of transformed cells. A host of molecules, factors, and conditions have been …
survival of transformed cells. A host of molecules, factors, and conditions have been …
Predicting cancer drug response using a recommender system
Motivation As we move toward an era of precision medicine, the ability to predict patient-
specific drug responses in cancer based on molecular information such as gene expression …
specific drug responses in cancer based on molecular information such as gene expression …
Polygenic risk scores in clinical psychology: bridging genomic risk to individual differences
R Bogdan, DAA Baranger… - Annual review of clinical …, 2018 - annualreviews.org
Genomewide association studies (GWASs) across psychiatric phenotypes have shown that
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
Determining the optimal dose in the development of anticancer agents
RHJ Mathijssen, A Sparreboom, J Verweij - Nature reviews Clinical …, 2014 - nature.com
Identification of the optimal dose remains a key challenge in drug development. For cytotoxic
drugs, the standard approach is based on identifying the maximum tolerated dose (MTD) in …
drugs, the standard approach is based on identifying the maximum tolerated dose (MTD) in …
Personalized pharmacogenomics: predicting efficacy and adverse drug reactions
M Pirmohamed - Annual review of genomics and human …, 2014 - annualreviews.org
Drug response varies between individuals owing to disease heterogeneity, environmental
factors, and genetic factors. Genetic factors can affect both the pharmacokinetics and …
factors, and genetic factors. Genetic factors can affect both the pharmacokinetics and …