Platelets are small anucleate cells present in the blood stream, their typical role in primary
hemostasis has been well-described. However, new evidence suggests that they have …

The interaction between circulating tumor cells and platelets is a key factor in cancer
metastasis. These interactions, driven by a variety of receptors, support circulating tumor …

Extracellular adenosine triphosphate (eATP) and its main metabolite adenosine (ADO)
constitute an intrinsic part of immunological network in tumor immunity. The concentrations …

The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic
drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted …

Cancer metastasis, defined by the epithelial to mesenchymal transition (EMT) of tumor cells,
disseminates from the primary site to progressively colonize in distant tissues, and accounts …

Colorectal (CRC) and hepatocellular carcinoma (HCC) are associated with chronic
inflammation, which plays a role in tumor development and malignant progression. An …

Cancer tissues are not just simple masses of malignant cells, but rather complex and
heterogeneous collections of cellular and even non-cellular components, such as …

P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its
well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic …

Cancer patients experience a four-fold increase in thrombosis risk, indicating that cancer
development and progression are associated with platelet activation. Xenograft experiments …

It is well known that various inflammatory cells infiltrate cancer cells. Next to TAMs (tumor-
associated macrophages), TAFs (tumor-associated fibroblasts) and TANs (tumor-associated …