Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …

SARS-CoV-2 viral load and detection of infectious virus in the respiratory tract are the two
key parameters for estimating infectiousness. As shedding of infectious virus is required for …

Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future
outbreaks,,,–, give rise to highly divergent lineages,–and contribute to cases with post-acute …

Background Viral rebound after nirmatrelvir–ritonavir treatment has implications for the
clinical management and isolation of patients with COVID-19. We evaluated an unselected …

Early treatment with a first-line therapy (nirmatrelvir/ritonavir [Paxlovid] or remdesivir) or
second-line therapy (molnupiravir) prevents hospitalization and death among patients with …

In a pivotal trial (EPIC-HR), a 5-day course of oral ritonavir-boosted nirmatrelvir, given early
during symptomatic SARS-CoV-2 infection (within three days of symptoms onset) …

Infectious virus shedding from individuals infected with severe acute respiratory syndrome-
coronavirus 2 (SARS-CoV-2) is used to estimate human-to-human transmission risk. Control …

Estimating the differences in the incubation-period, serial-interval, and generation-interval
distributions of SARS-CoV-2 variants is critical to understanding their transmission …

Objectives: High viral load in upper respiratory tract specimens observed for Delta cases
might contribute to its increased infectivity compared to the other variant. However, it is not …

The emergence and worldwide dissemination of SARS-CoV-2 required both urgent
development of new diagnostic tests and expansion of diagnostic testing capacity on an …