X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism1.
Here we describe the crystal and solution structures of a Bcl-2 family member, Bcl-xL (ref. 2) …
Here we describe the crystal and solution structures of a Bcl-2 family member, Bcl-xL (ref. 2) …
[HTML][HTML] Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator: coactivator interactions
The nuclear factor CREB activates transcription of target genes in part through direct
interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent …
interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent …
Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein
AS Kim, LT Kakalis, N Abdul-Manan, GA Liu… - Nature, 2000 - nature.com
Abstract The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through
activation of Wiskott–Aldrich syndrome protein (WASP) family members. Activation relieves …
activation of Wiskott–Aldrich syndrome protein (WASP) family members. Activation relieves …
[HTML][HTML] A novel mode of DNA recognition by a β‐sheet revealed by the solution structure of the GCC‐box binding domain in complex with DNA
The 3D solution structure of the GCC‐box binding domain of a protein from Arabidopsis
thaliana in complex with its target DNA fragment has been determined by heteronuclear …
thaliana in complex with its target DNA fragment has been determined by heteronuclear …
[HTML][HTML] Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20
Y Abe, T Shodai, T Muto, K Mihara, H Torii… - Cell, 2000 - cell.com
Most mitochondrial proteins are synthesized in the cytosol as precursor proteins with a
cleavable N-terminal presequence and are imported into mitochondria. We report here the …
cleavable N-terminal presequence and are imported into mitochondria. We report here the …
Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil
The pathogenesis of Alzheimer's disease is characterized by the aggregation and fibrillation
of amyloid peptides Aβ1–40 and Aβ1–42 into amyloid plaques. Despite strong potential …
of amyloid peptides Aβ1–40 and Aβ1–42 into amyloid plaques. Despite strong potential …
[LIVRE][B] NMR spectroscopy
GS Rule, TK Hitchens - 2006 - Springer
Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique that can be used
to investigate the structure, dynamics, and chemical kinetics of a wide range of biochemical …
to investigate the structure, dynamics, and chemical kinetics of a wide range of biochemical …
Impact of N-terminal acetylation of α-synuclein on its random coil and lipid binding properties
N-Terminal acetylation of α-synuclein (aS), a protein implicated in the etiology of Parkinson's
disease, is common in mammals. The impact of this modification on the protein's structure …
disease, is common in mammals. The impact of this modification on the protein's structure …
Local structural elements in the mostly unstructured transcriptional activation domain of human p53
DNA transcription is initiated by a small regulatory region of transactivators known as the
transactivation domain. In contrast to the rapid progress made on the functional aspect of …
transactivation domain. In contrast to the rapid progress made on the functional aspect of …
[HTML][HTML] Structure and functional interactions of the Tsg101 UEV domain
O Pornillos, SL Alam, RL Rich, DG Myszka… - The EMBO …, 2002 - embopress.org
Human Tsg101 plays key roles in HIV budding and in cellular vacuolar protein sorting
(VPS). In performing these functions, Tsg101 binds both ubiquitin (Ub) and the PTAP …
(VPS). In performing these functions, Tsg101 binds both ubiquitin (Ub) and the PTAP …