[HTML][HTML] Molecular dynamics simulations of the delta and omicron SARS-CoV-2 spike–ACE2 complexes reveal distinct changes between both variants

E Socher, L Heger, F Paulsen, F Zunke… - Computational and …, 2022 - Elsevier
Abstract SARS-CoV-2, the virus causing the COVID-19 pandemic, changes frequently
through the appearance of mutations constantly leading to new variants. However, only few …

[PDF][PDF] Covid-19 variants: impact on transmissibility and virulence

YA Malik - The Malaysian journal of pathology, 2022 - mjpath.org.my
The genetic evolution of SARS-CoV-2 began in February 2020, with G614 spike protein
strains superseding D614 strains globally. Since then with each subsequent mutations, the …

Research progress of spike protein mutation of SARS-CoV-2 mutant strain and antibody development

X Huan, J Zhan, H Gao - Frontiers in Immunology, 2024 - frontiersin.org
The coronavirus disease 2019 (COVID-19) is a respiratory disease with a very high
infectious rate caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS …

[HTML][HTML] In silico screening of phenylethanoid glycosides, a class of pharmacologically active compounds as natural inhibitors of SARS-CoV-2 proteases

CFAR Cheohen, MEA Esteves, TS da Fonseca… - Computational and …, 2023 - Elsevier
Since the advent of Covid-19, several natural products have been investigated regarding
their in silico interactions with SARS-CoV-2 proteases˗ 3CL pro and PL pro, two of the most …

[HTML][HTML] Early introduction, dispersal and evolution of Delta SARS-CoV-2 in Southern Brazil, late predominance of AY. 99.2 and AY. 101 related lineages

JS Gularte, MS da Silva, ACS Mosena, M Demoliner… - Virus Research, 2022 - Elsevier
The emergence of Variants of Concern (VOC) presenting an unusual number of new
mutations is one of the most remarkable features of SARS-CoV-2. The Delta variant, since its …

Deciphering the impact of mutations on the binding efficacy of SARS-CoV-2 omicron and delta variants with human ACE2 receptor

A Khan, SA Khan, K Zia, MS Altowyan… - Frontiers in …, 2022 - frontiersin.org
The pandemic of COVID-19, caused by SARS-CoV-2, has globally affected the human
health and economy. Since the emergence of the novel coronavirus SARS-CoV-2, the life …

Effect of double mutation (L452R and E484Q) on the binding affinity of monoclonal antibodies (MAbs) against the RBD—a target for vaccine development

D Gupta, M Kumar, P Sharma, T Mohan, A Prakash… - Vaccines, 2022 - mdpi.com
The COVID-19 pandemic, caused by SARS-CoV-2, emerges as a global health problem, as
the viral genome is evolving rapidly to form several variants. Advancement and progress in …

Molecular dynamics study on the strengthening behavior of Delta and Omicron SARS-CoV-2 spike RBD improved receptor-binding affinity

K Kodchakorn, P Kongtawelert - PloS one, 2022 - journals.plos.org
The COVID-19 pandemic caused by a virus that can be transmitted from human to human
via air droplets has changed the quality of life and economic systems all over the world. The …

Delta variant: Partially sensitive to vaccination, but still worth global attention

M Zhang, Y He, Z Jie - Journal of Translational Internal Medicine, 2022 - degruyter.com
The pandemic coronavirus disease 2019 (COVID-19) has rapidly spread to all countries
worldwide. The emergence of its variants has exacerbated this problem. To date, many …

Spatiotemporal evolution and transmission dynamics of Alpha and Delta SARS-CoV-2 variants contributing to sequential outbreaks in Cambodia during 2021

YCF Su, MA Zeller, TP Ou, J Ma, L Pum… - Communications …, 2024 - nature.com
Background Tracking the emergence, introduction and spread of SARS-CoV-2 variants of
concern are essential for informing public health strategies. In 2021, Cambodia faced two …