Seeing the membrane from both sides now: lipid asymmetry and its strange consequences

M Doktorova, I Levental… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Almost all biomembranes are constructed as lipid bilayers and, in almost all of these, the two
opposing monolayers (leaflets) have distinct lipid compositions. This lipid asymmetry arises …

Experimentally determined leaflet–leaflet phase diagram of an asymmetric lipid bilayer

TA Enoki, FA Heberle - Proceedings of the National Academy of Sciences, 2023 - pnas.org
We have determined the partial leaflet–leaflet phase diagram of an asymmetric lipid bilayer
at ambient temperature using asymmetric giant unilamellar vesicles (aGUVs). Symmetric …

The interplay of composition and mechanics in the thermodynamics of asymmetric ternary lipid membranes

M Varma, M Deserno - Faraday Discussions, 2024 - pubs.rsc.org
Eukaryotic lipid membranes are both compositionally complex and strongly asymmetric.
Preferential lipid interactions enable coexistence between two fluid phases and an …

With lipid rafts, context is everything

FA Heberle - Biophysical Journal, 2019 - cell.com
The lipid makeup of the mammalian plasma membrane (PM) continues to hold the
fascination of biophysicists. Although it has long been known that the PM contains hundreds …

[PDF][PDF] Exploring the Plasma Membrane Lipid Interactions and Properties in Experimental Models

IS Oliveira, GX Pinheiro, MLB Sa, PHLO Gurgel… - 2024 - preprints.org
This mini review intends to highlight the importance of bilayer asymmetry. Biological
membranes are complex structures that are a physical barrier separating the external …