Genome-wide association studies in diverse populations

NA Rosenberg, L Huang, EM Jewett… - Nature Reviews …, 2010 - nature.com
Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …

Status of cardiovascular disease and stroke in Hispanics/Latinos in the United States: a science advisory from the American Heart Association

CJ Rodriguez, M Allison, ML Daviglus, CR Isasi… - Circulation, 2014 - Am Heart Assoc
Background and Purpose—This American Heart Association (AHA) scientific statement
provides a comprehensive overview of current evidence on the burden cardiovascular …

Sensitive detection of chromosomal segments of distinct ancestry in admixed populations

AL Price, A Tandon, N Patterson, KC Barnes… - PLoS …, 2009 - journals.plos.org
Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of
applications from disease map** to learning about history. Most methods require the use …

Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America

R Kosoy, R Nassir, C Tian, PA White, LM Butler… - Human …, 2009 - Wiley Online Library
To provide a resource for assessing continental ancestry in a wide variety of genetic studies,
we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs) …

Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico

I Silva-Zolezzi, A Hidalgo-Miranda… - Proceedings of the …, 2009 - National Acad Sciences
Mexico is develo** the basis for genomic medicine to improve healthcare of its population.
The extensive study of genetic diversity and linkage disequilibrium structure of different …

Geographic patterns of genome admixture in Latin American Mestizos

S Wang, N Ray, W Rojas, MV Parra, G Bedoya… - PLoS …, 2008 - journals.plos.org
The large and diverse population of Latin America is potentially a powerful resource for
elucidating the genetic basis of complex traits through admixture map**. However, no …

Variant in PNPLA3 is associated with alcoholic liver disease

C Tian, RP Stokowski, D Kershenobich, DG Ballinger… - Nature …, 2010 - nature.com
Two genome-wide association studies (GWAS) have described associations of variants in
PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the …

Estimating local ancestry in admixed populations

S Sankararaman, S Sridhar, G Kimmel… - The American Journal of …, 2008 - cell.com
Large-scale genoty** of SNPs has shown a great promise in identifying markers that
could be linked to diseases. One of the major obstacles involved in performing these studies …

Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas

JM Galanter, JC Fernandez-Lopez, CR Gignoux… - PLoS …, 2012 - journals.plos.org
Most individuals throughout the Americas are admixed descendants of Native American,
European, and African ancestors. Complex historical factors have resulted in varying …

Interethnic admixture and the evolution of Latin American populations

FM Salzano, M Sans - Genetics and molecular biology, 2014 - SciELO Brasil
A general introduction to the origins and history of Latin American populations is followed by
a systematic review of the data from molecular autosomal assessments of the …