Conventional pulmonary function tests appear normal in early cystic fibrosis (CF) lung
disease. Therefore, new diagnostic approaches are required that can detect CF lung …

Fluorine‐19 (19F) MRI using inhaled inert fluorinated gases is an emerging technique that
can provide functional images of the lungs. Inert fluorinated gases are nontoxic, abundant …

Rationale and Objectives Ventilation heterogeneity is impossible to detect with spirometry.
Alternatively, pulmonary ventilation can be imaged three-dimensionally using inhaled 129 …

Purpose To quantify regional lung ventilation in patients with chronic obstructive pulmonary
disease (COPD) by using free-breathing dynamic fluorinated (fluorine 19 [19F]) gas …

Hyperpolarized (HP) xenon‐129 (129Xe) brain MRI is a promising imaging modality
currently under extensive development. HP 129Xe is nontoxic, capable of dissolving in …

Purpose To explore the feasibility of measuring ventilation defect percentage (VDP) using
19F MRI during free‐breathing wash‐in of fluorinated gas mixture with postacquisition …

Rationale and Objectives Hyperpolarized xenon-129 magnetic resonance (MR) provides
sensitive tools that may detect early stages of lung disease in smokers before it has …

Purpose To demonstrate the feasibility of compressed sensing (CS) to accelerate the
acquisition of hyperpolarized (HP) 129Xe multi‐b diffusion MRI for quantitative assessments …

Respiratory diseases are leading causes of death and disability in the world. While early
diagnosis is key, this has proven difficult due to the lack of sensitive and non-invasive tools …

Abstract Ventilation-perfusion (VA/Q) matching, the regional matching of the flow of fresh gas
to flow of deoxygenated capillary blood, is the most important mechanism affecting the …