Ovarian carcinoma is characterized by heterogeneity at the molecular, cellular and
anatomical levels, both spatially and temporally. This heterogeneity affects response to …

Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …

Transcriptional heterogeneity among malignant cells of a tumor has been studied in
individual cancer types and shown to be organized into cancer cell states; however, it …

Chemotherapy resistance is a critical contributor to cancer mortality and thus an urgent
unmet challenge in oncology. To characterize chemotherapy resistance processes in high …

Malignant abdominal fluid (ascites) frequently develops in women with advanced high-
grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor …

Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial
cancers are primarily imported from either endometrial or fallopian tube epithelium. The …

Following a period of slow progress, the completion of genome sequencing and the
paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led …

Cervical cancer (CC) is the most common gynecological malignancy, whose cellular
heterogeneity has not been fully understood. Here, we performed single-cell RNA …

COVID-19 patients always develop multiple organ dysfunction syndromes other than lungs,
suggesting the novel virus SARS-CoV-2 also invades other organs. Therefore, studying the …

Background Considerable evidence suggests that the heterogeneity of ovarian cancer (OC)
is a major cause of treatment failure. Single-cell RNA sequencing (scRNA-seq) is a powerful …