Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …

Cell-type-specific gene expression is physiologically modulated by the binding of
transcription factors to genomic enhancer sequences, to which chromatin modifiers such as …

Interactions between lineage-determining and activity-dependent transcription factors
determine single-cell identity and function within multicellular tissues through incompletely …

Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its
prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can …

Diabetic dysbiosis has been described as a novel key player in diabetes and diabetic
complications. However, the cellular/molecular alterations associated with dysbiosis remain …

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, with its
prevalence linked to both genetic predisposition and environmental factors. Epigenetic …

Butyrate, a gut microbial metabolite, has beneficial effects on glucose homeostasis and has
become an attractive drug candidate for type 2 diabetes (T2D). Recently, we showed that …

Little information is available regarding mechanistic links between epigenetic modifications
and autoimmune diseases. It seems plausible to surmise that aberrant gene expression and …

Pancreatic beta cell dysfunction caused by metabolic and inflammatory stress contributes to
the development of type 2 diabetes (T2D). Butyrate, produced by the gut microbiota, has …

The histone deacetylase HDAC3 is a critical mediator of hepatic lipid metabolism, and liver-
specific deletion of HDAC3 leads to fatty liver. To elucidate the underlying mechanism, here …