Glioblastoma (GBM) remains the most lethal primary brain cancer largely due to recurrence
of treatment-resistant disease. Current therapies are ultimately ineffective as GBM tumour …

Microtubule proteins form a dynamic component of the cytoskeleton, and play key roles in
cellular processes, such as vesicular transport, cell motility and mitosis. Expression of …

Gliomas are malignant tumors in the central nervous system. Cuproptosis is a newly
discovered cell death mechanism targeting lipoylated tricarboxylic acid cycle proteins …

Ascl1 and Ngn2, closely related proneural transcription factors, are able to convert mouse
embryonic stem cells into induced neurons. Despite their similarities, these factors elicit only …

Glioblastomas (GBMs) are highly aggressive, infiltrative, and heterogeneous brain tumors
driven by complex genetic alterations. The basic-helix-loop-helix (bHLH) transcription …

Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to
engage the neuronal differentiation programme, but instead become locked in a pro …

Direct neuronal reprogramming, the process whereby a terminally differentiated cell is
converted into an induced neuron without traversing a pluripotent state, has tremendous …

The proneural transcription factor ASCL1 regulates neurogenesis and drives somatic cell
reprogramming into neurons. However, not all cell types can be reprogrammed by ASCL1 …

Pioneer transcription factors (TFs) present an important subtype of transcription factors
which are vital for cell programming during embryonic development and cellular memory …

Brain tumors are a large and heterogeneous group of neoplasms that affect the central
nervous system and include some of the deadliest cancers. Almost all the conventional and …