General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of
the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase …

Abstract SAGA (Spt-Ada-Gcn5-A cetyltransferase), an evolutionarily conserved
transcriptional co-activator among eukaryotes, is a large multi-subunit protein complex with …

Ataxin-7 maintains the integrity of S pt-A da-G cn5-A cetyltransferase (SAGA), an
evolutionarily conserved coactivator in stimulating preinitiation complex (PIC) formation for …

Neurodegenerative disorders, such as spinocerebellar ataxias (SCAs) and Alzheimer's
disease (AD) represent a huge scientific and medical question, but the molecular …

Spinocerebellar ataxias (SCAs) are a heterogeneous group of dominantly inherited
neurodegenerative disorders affecting the cerebellum and its associated pathways. There …

Perturbation of protein homeostasis and aggregation of misfolded proteins is a major cause
of many human diseases. A hallmark of the neurodegenerative disease spinocerebellar …

Abstract Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease
caused by the expansion of a CAG repeat within the ataxin 7 gene, leading to a pathogenic …

Spinocerebellar ataxias (SCA) are a family of dominantly-inherited neurodegenerative
disorders which affect movement and coordination. Patients experience the shared features …

A variety of developmental diseases of the cerebellum are associated with dysregulation of
proteins regulated by the ubiquitin proteasome system (UPS). Dysfunction of the UPS is …

Abstract Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative
disorder caused by a CAG trinucleotide expansion in the SCA7 gene, resulting in …