Disentangling heterogeneity in Alzheimer's disease and related dementias using data-driven methods
Brain aging is a complex process that includes atrophy, vascular injury, and a variety of age-
associated neurodegenerative pathologies, together determining an individual's course of …
associated neurodegenerative pathologies, together determining an individual's course of …
[HTML][HTML] Neurochemical changes in the aging brain: A systematic review
Magnetic resonance spectroscopy (MRS) holds promise for understanding neurochemical
mechanisms associated with human cognitive aging in vivo. Recent advances in magnetic …
mechanisms associated with human cognitive aging in vivo. Recent advances in magnetic …
Brain aging patterns in a large and diverse cohort of 49,482 individuals
Brain aging process is influenced by various lifestyle, environmental and genetic factors, as
well as by age-related and often coexisting pathologies. Magnetic resonance imaging and …
well as by age-related and often coexisting pathologies. Magnetic resonance imaging and …
[HTML][HTML] Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan
As medical imaging enters its information era and presents rapidly increasing needs for big
data analytics, robust pooling and harmonization of imaging data across diverse cohorts …
data analytics, robust pooling and harmonization of imaging data across diverse cohorts …
The Brain Chart of Aging: machine‐learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING …
Introduction Relationships between brain atrophy patterns of typical aging and Alzheimer's
disease (AD), white matter disease, cognition, and AD neuropathology were investigated via …
disease (AD), white matter disease, cognition, and AD neuropathology were investigated via …
[HTML][HTML] Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study
Brain age is becoming a widely applied imaging-based biomarker of neural aging and
potential proxy for brain integrity and health. We estimated multimodal and modality-specific …
potential proxy for brain integrity and health. We estimated multimodal and modality-specific …
Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging
The concept of brain maintenance refers to the preservation of brain integrity in older age,
while cognitive reserve refers to the capacity to maintain cognition in the presence of …
while cognitive reserve refers to the capacity to maintain cognition in the presence of …
[HTML][HTML] Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease
Abstract “Brain-predicted age” quantifies apparent brain age compared to normative
neuroimaging trajectories. Advanced brain-predicted age has been well established in …
neuroimaging trajectories. Advanced brain-predicted age has been well established in …
The maternal brain: Region‐specific patterns of brain aging are traceable decades after childbirth
Pregnancy involves maternal brain adaptations, but little is known about how parity
influences women's brain aging trajectories later in life. In this study, we replicated previous …
influences women's brain aging trajectories later in life. In this study, we replicated previous …
Measuring resilience and resistance in aging and Alzheimer disease using residual methods: a systematic review and meta-analysis
Background and Objective There is a lack of consensus on how to optimally define and
measure resistance and resilience in brain and cognitive aging. Residual methods use …
measure resistance and resilience in brain and cognitive aging. Residual methods use …