Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily
conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

When mammalian cells are deprived of glutamine, exogenous asparagine rescues cell
survival and growth. Here we report that this rescue results from use of asparagine in protein …

Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

Understanding how gene expression programs are controlled requires identifying regulatory
relationships between transcription factors and target genes. Gene regulatory networks are …

Genetically identical cells are known to differ in many physiological parameters such as
growth rate and drug tolerance. Metabolic specialization is believed to be a cause of such …

The ability to independently control the expression of different genes is important for
quantitative biology. Using budding yeast, we characterize GAL1pr, GALL, MET3pr, CUP1pr …

Genome-metabolism interactions enable cell growth. To probe the extent of these
interactions and delineate their functional contributions, we quantified the Saccharomyces …

The evolutionary conserved TOR complex 1 (TORC1) activates cell growth in response to
nutrients. In yeast, TORC1 responds to the nitrogen source via a poorly understood …

We review the mechanisms responsible for amino acid homeostasis in Saccharomyces
cerevisiae and other fungi. Amino acid homeostasis is essential for cell growth and survival …