Conformational analysis of complex protein states by hydrogen/deuterium exchange mass spectrometry (HDX-MS): Challenges and emerging solutions
E Trabjerg, ZE Nazari, KD Rand - TrAC Trends in Analytical Chemistry, 2018 - Elsevier
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has within the last 25 years
evolved to become a well-established technique for analysing the solution-phase …
evolved to become a well-established technique for analysing the solution-phase …
Structural basis of the pore-forming toxin/membrane interaction
Y Li, Y Li, HM Mengist, C Shi, C Zhang, B Wang, T Li… - Toxins, 2021 - mdpi.com
With the rapid growth of antibiotic-resistant bacteria, it is urgent to develop alternative
therapeutic strategies. Pore-forming toxins (PFTs) belong to the largest family of virulence …
therapeutic strategies. Pore-forming toxins (PFTs) belong to the largest family of virulence …
Structure and allosteric inhibition of excitatory amino acid transporter 1
Human members of the solute carrier 1 (SLC1) family of transporters take up excitatory
neurotransmitters in the brain and amino acids in peripheral organs. Dysregulation of the …
neurotransmitters in the brain and amino acids in peripheral organs. Dysregulation of the …
Calcium-driven folding of RTX domain β-rolls ratchets translocation of RTX proteins through type I secretion ducts
Calcium-binding RTX proteins are equipped with C-terminal secretion signals and
translocate from the Ca 2+-depleted cytosol of Gram-negative bacteria directly into the Ca …
translocate from the Ca 2+-depleted cytosol of Gram-negative bacteria directly into the Ca …
Structure of the calcium-dependent type 2 secretion pseudopilus
Many Gram-negative bacteria use type 2 secretion systems (T2SSs) to secrete proteins
involved in virulence and adaptation. Transport of folded proteins via T2SS nanomachines …
involved in virulence and adaptation. Transport of folded proteins via T2SS nanomachines …
An arsenal of methods for the experimental characterization of intrinsically disordered proteins–how to choose and combine them?
In this review, we detail the most common experimental approaches to assess and
characterize protein intrinsic structural disorder, with the notable exception of NMR and EPR …
characterize protein intrinsic structural disorder, with the notable exception of NMR and EPR …
Stimulating effect of graphene oxide on myogenesis of C2C12 myoblasts on RGD peptide-decorated PLGA nanofiber matrices
Background In the field of biomedical engineering, many studies have focused on the
possible applications of graphene and related nanomaterials due to their potential for use as …
possible applications of graphene and related nanomaterials due to their potential for use as …
MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets
Motivation: With the continued improvement of requisite mass spectrometers and UHPLC
systems, Hydrogen/Deuterium eXchange Mass Spectrometry (HDX-MS) workflows are …
systems, Hydrogen/Deuterium eXchange Mass Spectrometry (HDX-MS) workflows are …
Small-angle scattering studies of intrinsically disordered proteins and their complexes
TN Cordeiro, F Herranz-Trillo, A Urbanek… - Current opinion in …, 2017 - Elsevier
Highlights•Despite the absence of permanent structure, IDPs perform crucial functions in
biology.•Structural studies of IDPs require the combination of SAS with computation.• …
biology.•Structural studies of IDPs require the combination of SAS with computation.• …
Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins
A bscisic acid (ABA), s tress and r ipening (ASR) proteins are plant-specific proteins involved
in plant response to multiple abiotic stresses. We previously isolated the ASR genes and …
in plant response to multiple abiotic stresses. We previously isolated the ASR genes and …