Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix
that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic …

Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic
homeostasis are significant consequences of treatment. Here, we describe three postulates …

Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the
composition of gut microbiota and causing dysbiosis and disease. Despite this well-known …

Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to
discover new antibiotics. To address this challenge, we trained a deep neural network …

Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy
is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance …

The increasing emergence and dissemination of multidrug resistant (MDR) bacterial
pathogens accelerate the desires for new antibiotics. Natural products dominate the …

The spread of antibiotic resistance is attracting increased attention to combination-based
treatments. Although drug combinations have been studied extensively for their effects on …

Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

While often obvious for macroscopic organisms, determining whether a microbe is dead or
alive is fraught with complications. Fields such as microbial ecology, environmental health …

Recently, it was proposed that there is a common mechanism behind the activity of
bactericidal antibiotics, involving the production of reactive oxygen species (ROS). However …