Maintenance of endothelial cell integrity is an important component of human health and
disease since the endothelium can perform various functions including regulation of …

Hypertension is a leading risk factor for stroke, heart disease and chronic kidney disease.
Multiple interacting factors and organ systems increase blood pressure and cause target …

Hypertensive heart disease constitutes functional and structural dysfunction and
pathogenesis occurring primarily in the left ventricle, the left atrium and the coronary arteries …

Vascular disease was for a long time considered a disease of the old age, but it is becoming
increasingly clear that a cumulus of factors can cause early vascular aging (EVA) …

Exosomes are a pluripotent group of extracellular nanovesicles secreted by all cells that
mediate intercellular communications. The effective information within exosomes is primarily …

Salt-sensitivity of blood pressure is an independent risk factor for cardiovascular disease
and affects approximately half of the hypertensive population. While the precise …

Pyroptosis is a form of programmed cell death associated with activation of inflammasomes
and inflammatory caspases, proteolytic cleavage of gasdermin proteins (forming pores in the …

The nucleotide-binding domain leucine-rich repeat-receptor, pyrin domain-containing-3
(NLRP3) inflammasome contributes to the inflammatory response by activating caspase-1 …

Under physiological conditions, reactive oxygen species (ROS) function as signaling
molecules that control cell function. However in pathological conditions, increased …

The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial
fibrillation remains a serious global clinical issue, with ongoing need for novel approaches …