Relearning to see in cortical blindness

MD Melnick, D Tadin, KR Huxlin - The Neuroscientist, 2016 - journals.sagepub.com
The incidence of cortically induced blindness is increasing as our population ages. The
major cause of cortically induced blindness is stroke affecting the primary visual cortex …

Rehabilitation of visual perception in cortical blindness

EL Saionz, A Busza, KR Huxlin - Handbook of clinical neurology, 2022 - Elsevier
Blindness is a common sequela after stroke affecting the primary visual cortex, presenting as
a contralesional, homonymous, visual field cut. This can occur unilaterally or, less …

Spared perilesional V1 activity underlies training-induced recovery of luminance detection sensitivity in cortically-blind patients

A Barbot, A Das, MD Melnick, MR Cavanaugh… - Nature …, 2021 - nature.com
Damage to the primary visual cortex (V1) causes homonymous visual-field loss long
considered intractable. Multiple studies now show that perceptual training can restore visual …

Boosting learning efficacy with noninvasive brain stimulation in intact and brain-damaged humans

F Herpich, MD Melnick, S Agosta… - Journal of …, 2019 - Soc Neuroscience
Numerous behavioral studies have shown that visual function can improve with training,
although perceptual refinements generally require weeks to months of training to attain …

Fluoxetine-induced recovery of serotonin and norepinephrine projections in a mouse model of post-stroke depression

A Zahrai, F Vahid-Ansari, M Daigle, PR Albert - Translational psychiatry, 2020 - nature.com
Chronic treatment with fluoxetine (FLX) is required for its antidepressant effects, but the role
of serotonin (5-HT) axonal plasticity in FLX action is unknown. To address this, we examined …

Visual discrimination training improves Humphrey perimetry in chronic cortically induced blindness

MR Cavanaugh, KR Huxlin - Neurology, 2017 - AAN Enterprises
Objective: To assess if visual discrimination training improves performance on visual
perimetry tests in chronic stroke patients with visual cortex involvement. Methods: 24-2 and …

Rehabilitation of cortically induced visual field loss

EL Saionz, SE Feldon, KR Huxlin - Current Opinion in Neurology, 2021 - journals.lww.com
Research has uncovered substantial visual plasticity after occipital strokes, suggesting that
rehabilitative strategies for this condition should be more aggressive. For maximal benefit …

Optic tract shrinkage limits visual restoration after occipital stroke

BK Fahrenthold, MR Cavanaugh, S Jang, AJ Murphy… - Stroke, 2021 - Am Heart Assoc
Background and Purpose: Damage to the adult primary visual cortex (V1) causes vision loss
in the contralateral visual hemifield, initiating a process of trans-synaptic retrograde …

Feature-based attention potentiates recovery of fine direction discrimination in cortically blind patients

MR Cavanaugh, A Barbot, M Carrasco, KR Huxlin - Neuropsychologia, 2019 - Elsevier
Training chronic, cortically-blind (CB) patients on a coarse [left-right] direction discrimination
and integration (CDDI) task recovers performance on this task at trained, blind field …

Selective serotonin reuptake inhibitors for functional recovery after stroke: similarities with the critical period and the role of experience-dependent plasticity

CL Schneider, AK Majewska, A Busza, ZR Williams… - Journal of …, 2021 - Springer
There has been a growing interest in the potential for plasticity-inducing pharmacological
interventions to enhance post-stroke recovery. One group of drugs that continues to garner a …