Fluconazole resistance in Candida species: a current perspective

EL Berkow, SR Lockhart - Infection and drug resistance, 2017 - Taylor & Francis
Candida albicans and the emerging non-albicans Candida spp. have significant clinical
relevance among many patient populations. Current treatment guidelines include …

Mechanisms of antifungal drug resistance

LE Cowen, D Sanglard… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Antifungal therapy is a central component of patient management for acute and chronic
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …

Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens

E Ksiezopolska, T Gabaldón - Genes, 2018 - mdpi.com
Fungal infections, such as candidiasis caused by Candida, pose a problem of growing
medical concern. In developed countries, the incidence of Candida infections is increasing …

Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents

C Spampinato, D Leonardi - BioMed research international, 2013 - Wiley Online Library
The genus Candida includes about 200 different species, but only a few species are human
opportunistic pathogens and cause infections when the host becomes debilitated or …

Antifungal resistance and new strategies to control fungal infections

P Vandeputte, S Ferrari… - International journal of …, 2012 - Wiley Online Library
Despite improvement of antifungal therapies over the last 30 years, the phenomenon of
antifungal resistance is still of major concern in clinical practice. In the last 10 years the …

Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical …

TR Rogers, PE Verweij, M Castanheira… - Journal of …, 2022 - academic.oup.com
The increasing incidence and changing epidemiology of invasive fungal infections continue
to present many challenges to their effective management. The repertoire of antifungal drugs …

Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation

D Sanglard, A Coste, S Ferrari - FEMS yeast research, 2009 - academic.oup.com
Fungi are primitive eukaryotes and have adapted to a variety of niches during evolution.
Some fungal species may interact with other life forms (plants, insects, mammals), but are …

Regulation of multidrug resistance in pathogenic fungi

J Morschhäuser - Fungal Genetics and Biology, 2010 - Elsevier
Infections by opportunistic pathogenic fungi, especially Candida species, Cryptococcus
neoformans, and Aspergillus fumigatus, are a serious medical problem in …

Update on antifungal drug resistance

DS Perlin, E Shor, Y Zhao - Current clinical microbiology reports, 2015 - Springer
Invasive fungal infections remain a major source of global morbidity and mortality, especially
among patients with underlying immune suppression. Successful patient management …

Analysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing

K Spettel, W Barousch, A Makristathis, I Zeller, M Nehr… - PloS one, 2019 - journals.plos.org
Introduction/Objectives An increase in antifungal resistant Candida strains has been
reported in recent years. The aim of this study was to detect mutations in resistance genes of …